Back in April 2019, an experimental study underway at the University of Pennsylvania made news for its success in using gene editing to treat a form of malignant cancer. Researchers genetically-altered immune cells (specifically, T cells) to encourage them to attack and destroy cancer cells, and managed to cure a patient of sarcoma – a cancer of the soft tissues like muscle, tendons, fat, lymph vessels, blood vessels, and nerves.
Now, three people with advanced stages of cancer have received similarly altered-immune cells, that were gene-edited using a technology called CRISPR, without any notable side effects. This is the first clinical trial of the technique as a treatment in the US, and the first CRISPR cancer trial to publish its findings.
Since the year 2010, when gene-editing technology first surfaced as a genetic engineering tool, the entire field of genetics (and to some extent, biology as a whole) underwent a revolution. The first use of gene editing in experiments was in 2013. CRISPR has been cited in almost 3 lakh published papers, of which many are breakthroughs of their own. In those nine years, CRISPR has become a promising tool in curing over 6,000 unique conditions.
The purpose of the US trial was mainly to address how safe the technique was, and its feasibility as a treatment method, and not to find a cure. In this objective, the trail was a big success. All three patients, in their 60s, had stubborn tumors that didn't respond to any earlier treatments.
They were each given a dose of CRISPR-altered versions of their own T cells in April 2019, with minor alterations made to these cells to make them more efficient at recognizing and targetting a specific cancer protein. This CRISPR-enhanced T-cell would then dutifully attack the cancer cell, as it would any other infected or irregular cell flagged for nixing.
The researchers found that these CRISPR-modified cells fit right into each patient’s immune system, still found in their blood nine months later. This is the first known success of its kind in using CRISPR in humans to treat an ailment with no serious side-effects till date. The results of the trial were published in Science.
from Firstpost Tech Latest News https://ift.tt/2ONJ3ZY
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